Umbilical cord stem cells show promise as heart failure treatment

Study Highlights

  • Intravenous stem cell infusion produced from umbilical cords seems to improve heart muscle function in patients with heart failure, based on a little study.
  • Within this first-of-its-kind study, patients had “significant” improvement within their hearts’ capability to pump bloodstream and experienced no adverse negative effects associated with the treatment.
  • The outcomes suggest IV-infused umbilical cord-derived stem cells really are a promising avenue to deal with heart failure.

Embargoed until 3 p.m. CT / 4 p.m. ET Tuesday, September 26, 2017

DALLAS, Sept. 26, 2017 – A heart failure treatment using umbilical cord-derived stem cells can lead to notable enhancements in heart muscle function and excellence of existence, according to a different study printed in Circulation Research, a united states Heart Association journal.

“We are encouraged by our findings simply because they could pave the best way to a non-invasive, promising new therapy for several patients who face harsh odds,” stated study corresponding author Fernando Figueroa, M.D., professor of drugs in the Universidad de los Andes in Chile.

Within this trial, 30 volunteers, ages 18 to 75, with stable heart failure receiving optimal drug therapy went through intravenous infusions with either umbilical cord-derived stem cells or placebo. The umbilical cords were acquired from full-term human placentas from healthy contributors by caesarean section after informed consent.

When compared to placebo treatment, the stem cell therapy:

  • demonstrated sustained and “significant” improvement within the hearts’ capability to pump bloodstream around following treatment
  • led to greater enhancements on measures of daily functional status and excellence of existence and
  • was safe without any negative effects or growth and development of alloantibodies, a typical immune complication in patients receiving organ transplants or bloodstream transfusions.

Scientific study has formerly assessed the potential for bone marrow-derived stem cells as treatment however, intravenous umbilical cord-derived stem cells haven’t been evaluated. The second type continues to be particularly appealing since they’re readily available, broadly available, unlikely to result in immune complications and free from the moral concerns that surround embryonic stem cells, they noted.

“Standard drug-based regimens could be suboptimal in managing heart failure, and patients frequently need to progress to more invasive therapies for example mechanical ventricular assist devices and heart transplantation,” stated lead study author Jorge Bartolucci M.D., a cardiologist from Cells for Cells and professor in the Universidad de los Andes.

Heart failure, marked through the heart muscle’s lack of ability to function bloodstream efficiently, affects some 37 million people worldwide. Despite medical advances, 1 / 2 of patients identified as having heart failure will die within 5 years of diagnosis, based on Figueroa. If affirmed in bigger studies, these bits of information could give a promising new treatment choice for a disorder that presently has couple of.   

Other co-authors incorporated Fernando J. Verdugo, M.D. Paz L. González, B.Sc. Ricardo E. Larrea, M.D. Ema Abarzua, M.D. Carlos Goset, M.D. Pamela Rojo, M.D. Ivan Palma, M.D. Ruben Lamich, M.D. Pablo A. Pedreros, M.D. Gloria Valdivia, Ph.D. Valentina M. Lopez, B.Sc. Carolina Nazzal, Ph.D. Francisca Alcayaga, Ph.D. Jimena Cuenca, Ph.D. Matthew J. Brobeck, B.Sc. Amit N. Patel, M.D. and Maroun Khoury, Ph.D. Author disclosures take presctiption the manuscript.

The research was funded with a grant from CORFO, the Chilean Economic Development Agency.

Additional Sources:

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