Severe heart failure might be reversible

heart health concept art
It might be entirely possible that a recently discovered cardiovascular repair process could reverse heart failure.
Scientists might have discovered a means of reversing heart failure through getting heart muscle to regenerate itself.

They discovered that silencing a signaling path in rodents which had developed heart failure following cardiac arrest activated a formerly unrecognized self-recovery process.

Inside a paper lately printed within the journal Nature, they, brought with a team from Baylor College of drugs in Houston, Texas, report their findings concerning the signaling path, which is called Hippo.

Heart failure is really a serious condition that affects around 5.seven million adults within the U . s . States. It develops once the heart cannot pump enough bloodstream to satisfy your body’s needs.

Heart failure does not necessarily mean the heart has stopped pumping, however it entails that vital organs don’t get the nutrients and oxygen they have to function correctly. Around 1 / 2 of patients with heart failure don’t live greater than five years after diagnosis.

“Heart failure continues to be the leading reason for mortality from cardiovascular disease,Inch explains corresponding author James F. Martin, a professor which specializes in regenerative medicine at Baylor College of drugs and who’s also director from the Cardiomyocyte Renewal Lab in the Texas Heart Institute, and in Houston.

Hurt hearts favor scarring to regeneration

At the moment, the very best strategy to heart failure is really a heart transplant. However, the amount of heart failure patients exceeds the amount of hearts readily available for transplant. Getting a ventricular assist device implanted can also be a choice, but it’s a significantly less favorable one.

Among the curious reasons for heart muscle is it doesn’t regenerate if this dies after being starved of oxygen, for example after cardiac arrest.

Rather of generating new beating muscle tissues, or cardiomyocytes, the center replaces the dead tissue with scarring produced from fibroblast cells.

Unlike cardiomyocytes, fibroblasts don’t have any pumping ability, therefore the heart progressively will get less strong and less strong, which means that nearly all severe cardiac arrest patients develop heart failure.

Prof. Martin states he and the laboratory team are studying biological pathways which are active during heart development and regeneration to find methods to heal heart muscle.

Biological pathways are number of molecular occasions inside cells that cause alterations in the cell or lead to particular products. For instance, they are able to turn genes off and on plus they can trigger cells to create fats, proteins, hormones, along with other molecules. They may also carry signals and cause cells to maneuver.

Silencing the Hippo path

“Within this study, we investigated the Hippo path, that is known from my lab’s previous studies to avoid adult heart muscle cell proliferation and regeneration,” Prof. Martin notes.

Within their study paper, he and the colleagues explain the Hippo path – “a kinase cascade that stops adult cardiomyocyte proliferation and regeneration” – is much more active in patients with heart failure.

“This,” says first author John Leach, a graduate student of molecular physiology and biophysics in Prof. Martin’s group, “brought us to consider when we’re able to turn Hippo off, only then do we could possibly induce improvement in heart function.”

So, they silenced the Hippo path inside a mouse model that mimics the kind of advanced heart failure occurring in humans after cardiac arrest. They compared the outcomes with individuals of several healthy rodents (the controls).

“After 6 days we observed the hurt hearts had retrieved their pumping function to the stage from the control, healthy hearts,” states Leach.

The researchers think that silencing Hippo not just renews heart muscle tissues – as investigated extensively within their study – it changes the entire process of fibrosis, or scarring. They require further studies to research the results on fibrosis.

Our findings indicate the failing heart includes a formerly unrecognized reparative capacity involving greater than cardiomyocyte renewal.”

Hollywood producer pens memoir about heart surgery, existence

By AMERICAN HEART ASSOCIATION NEWS

An enthusiastic golfer, Richard Very was having a day around the course with buddies as he recognized something wasn’t right. He’d a burning sensation in the chest. Then his heart started beating quickly.

Fortunately, he didn’t delay in seeing his cardiologist. He found that he needed his aortic valve replaced. He would need to undergo open-heart surgery.

It amazed Very how rapidly occasions required place dads and moms before his operation in Feb 2009, because he met with doctors coupled with pre-op procedures. The morning from the surgery, the enormity of the items he faced hit him hard.

“Holy cow, this is actually happening,” he remembered thinking.

Not just did Very endure major surgery, but he worked having a hurry of ideas and feelings. Encouraged by his wife, Fran, he authored inside a journal on the way. His notes brought to more intensive writing throughout his recovery and, eventually, to his new book, Journey from the Heart.

The memoir details his medical encounters and the close family bonds. It moves backwards and forwards between scenes at Cedars-Sinai Clinic in La and recollections of accelerating in New You are able to, falling for each other and starting your show business career.

His cardiologist, Ilan Kedan, M.D., thought it might be helpful for other heart patients. Actually, a heart transplant recipient received an earlier copy and thanked Very for that comfort it gave her.

“That just thrilled me,” he stated. “To realize that something I’ve written might help people overcome their fears is amazingly gratifying.”

Writing is really a natural for Very, a Hollywood producer and author who in 2013 authored his first novel, A Reign Supreme, printed by Open Road Media.

“Richard has always were built with a pencil and pad at his side,” Fran stated. “His office is filled with pads he has accrued for a long time, filled with memos, plans, story ideas and descriptions for TV projects.”

He even required copious notes about Fran’s extended labor when their daughter, Jackie, was created.

Recognized to many by his childhood nickname, Rip, he increased up inside an imaginative family. His older brother, Joel, were built with a talent for drawing and grew to become craft creativity educator. His more youthful brother is actor and comedian Billy Very. Their father, Jack, created jazz concerts and ran the Commodore Music Shop in Manhattan. Their mother, Helen, encouraged her sons in class plays and sports.

Helen Crystal in 1990 with her sons, from left, Richard, Joel and Billy. (Photo from

Helen Very in 1990 together with her sons, from left, Richard, Joel and Billy. (Photo from “Journey from the Heart” thanks to Richard Very)

For Rip, writing the memoir would be a creative outlet and a method to keep anxiety away, Fran stated.

It features a forward by basketball legend Kareem Abdul-Jabbar, who also offers gone through heart surgery. Crystal’s memoir explains his medical encounters in vivid detail to ensure that others can know what to anticipate.

His scariest there was a time after surgery one evening when his degree of energy dropped and that he worried he may die. A physician later described he had hit a wall, of sorts, that happens when our body’s surgery-related adrenaline hurry subsides.

Richard Crystal before his heart valve surgery in 2009. (Photo from

Richard Very before his heart valve surgery in ’09. (Photo from “Journey from the Heart” thanks to Richard Very)

“When I just read it, I’m back there,” stated Very, who continued to be within the hospital five nights after surgery.

He’s glad his physician had him pay attention to his heartbeat pre and post surgery because individuals particularly different sounds made Very realize the significance of getting the valve substitute.

Family and buddies helped tremendously, he stated.

“It’s huge,” he stated. “They have the back. It’s so comforting, and it offers a superior enormous confidence.”

Relatives introduced meals for their home for 3 days, Fran stated, and buddies and family came by to accompany her husband on neighborhood walks.

Very, now 71, had the surgery yesterday his 63rd birthday. His brother Billy helped by telling him the operation will be the best present he could find yourself getting.

Additionally towards the valve substitute, Very were built with a single artery bypass on that day. He received publish-surgery cardiac rehabilitation, doing monitored aerobic activity.

Today, he visits his cardiologist annually to watch his new heart valve. He eats healthy and stays fit by riding particular and dealing with light weights. Also, he plays golf two times per week and walks the program.

Richard Crystal holds 1-month-old grandson Maxwell Henry on Father's Day in 2015 alongside his son-in-law Lee, wife Fran, daughter Jackie and granddaughter Coco. (Photo from

Richard Very holds 1-month-old grand son Maxwell Henry on Father’s Day in 2015 alongside his boy-in-law Lee, wife Fran, daughter Jackie and daughter Coco. (Photo from “Journey from the Heart” thanks to Richard Very)

Very can also be getting associated with the American Heart Association. He took part in a Heart Walk-in the la area in September and it is supplying the patient’s perspective at another local event.

When signs and symptoms appear, don’t ignore them, he warns. And, Very urges fellow patients to trust their medical team.

“There’s lots of anxiety, understandably,” he stated. “But you just need to have belief and rely upon the folks assisting you, and it will be OK.”

Journey from the Heart can be obtained at online booksellers and thru Title Town Publishing. For those who have questions or comments relating to this story, please email [email protected].

After battling cardiovascular disease, Wisconsin transplant recipient requires to the roads of the usa

By AMERICAN HEART ASSOCIATION NEWS

Quadruple bypass surgery at 39 and cardiac arrest nine years later left Jerry McCann unsure what his future would hold.

Helped by an implanted defibrillator, Jerry forged ahead. Later, he battled high bloodstream pressure, dizziness and fatigue. Doctors diagnosed congestive heart failure, another blow.

“I could do much less,Inches he stated.

This Year, Jerry was on the heart transplant waiting list after which was put on a left ventricular assist device, or LVAD, that is surgically implanted to assist the center pump bloodstream with the body. Sometimes the mechanical products are temporary until a heart transplant occurs. But may they’re permanent.

“That would be a very hard decision for me personally because I didn’t wish to be alive due to a machine,” he stated.

Others experienced in LVADs helped. One lady place it in perspective by explaining, “We have to understand that we’re on God’s time, not our very own.Inches

For nearly 2 yrs, Jerry continued to be tethered towards the device’s 15-feet cord and base unit during the night and moved around having a battery power throughout the day. His wife, Margaret, replaced the dressing of his cut every single day.

Jerry had brought an energetic existence. He would be a restaurant manager for a long time as well as in mid-existence grew to become a auto technician in a course. He is another motorcycle enthusiast. However the McCanns kept away from traveling as they was around the transplant list. They have to stay close to the hospital in situation a donor heart grew to become available.

Jerry and Margaret McCann at the Heart Walk at Sherwood Island State Park in Westport, Conn., in April. (Photo courtesy of Carolyn Torella)

Jerry and Margaret McCann in the centre Walk at Sherwood Island Condition Park in Westport, Conn., in April. (Photo thanks to Carolyn Torella)

One evening in This summer 2014 the decision came. Jerry was told to get at College of Wisconsin Hospital immediately for his transplant.

Surgery started the next morning, lasting greater than 10 hrs. He emerged with a brand new heart – along with a new existence ahead.

“I’m just very grateful to possess a second chance on existence,” he stated.

Margaret, describing the aftermath of her husband’s transplant, recalls an expression a healthcare facility used to celebrate the 50th anniversary of their transplant program: “Hope, meet gratitude.”

“It continues to be real revealing about things that are essential and things that aren’t that essential in existence,” she stated.

Jerry, now 65, volunteers for that transplant organization Donate Existence and visits drivers’ education classes to induce youthful individuals to register to get organ contributors.

The pair can also be on the mission: walk-in the American Heart Association’s Heart Walk-in all 50 states.

They launched their mix-country Heart Walk journey after participating using their grown kids in walks in Orlando and San antonio in 2015, annually following the transplant. McCann, while speaking together with his boy-in-law, considered the thought of reaching all 50 states.

“That type of snowballed the entire factor,” Jerry stated.

Jerry McCann in May at the Heart Walk in Omaha, Nebraska. (Photo courtesy of Margaret McCann)

Jerry McCann in May in the centre Walk-in Omaha, Nebraska. (Photo thanks to Margaret McCann)

They think it is “energizing” to satisfy fellow participants and lift awareness for cardiovascular disease and funding for scientific research.

Description of how the have finished Heart Walks in Florida, Washington, Wisconsin, Illinois, Iowa, Minnesota, Or, Arizona, Tennessee, Indiana, Missouri, New You are able to, Connecticut, Nebraska and South Dakota — 15 to date. Buddies and family sometimes join them.

The McCanns put on red T-shirts showing a U.S. map they color in because they go and bearing the language “Moving our ft and maintaining your beat one condition at any given time!Inches Jerry walks in tribute to his anonymous donor.

Certainly one of their recent walks in Omaha, Nebraska, would be a “grand adventure,” Margaret stated. “It would be a perfect morning along with a beautiful route within the Missouri River.”

Jerry loves to interact with other transplant recipients, who put on red hats and stick out within the walking crowd. His message to other people would be to “enjoy every single day.Inches

Nevada may be the next condition around the couple’s list, using the Vegas Heart Walk on Sept. 30. However comes the walk-in their hometown of Madison on Sept. 16.

“We’re creating for many quiet years,” he stated. “I just have to repay which help out wherever I’m able to.Inches

This past year, heart patient Fishing rod Carew battled through Hall of Fame weekend. This season, the transplant recipient demonstrated what lengths he’s come.

By AMERICAN HEART ASSOCIATION NEWS

Fishing rod Carew fist bumps certainly one of his many well-wishers during Hall of Fame weekend.

COOPERSTOWN, New You are able to – Fishing rod Carew walked lower a ramp outdoors the Baseball Hall of Fame, the ultimate legend departing your building carrying out a parade and reception. With every step, he heard clapping and also the sentiments frequently sent his way nowadays.

“Looking good, Fishing rod!” screamed among the roughly 40 fans still clustered behind a barricade next door almost three hrs following the parade.

“So glad you’re succeeding!Inches yelled another.

Seven several weeks taken off getting a new heart and kidney, Carew was overall a lengthy day that would’ve worn-out anybody. It would’ve been understandable if he’d waved towards the crowd, rose in to the waiting Sports utility vehicle and driven off.

Rather, Carew headed next door. He strolled across the railing, bumping fists, posing for pictures and exchanging small talk.

More than a weekend full of moments that underscored what lengths he’s are available in his combat cardiovascular disease, it was probably the most profound. The man who this past year at the moment needed to be helped interior and exterior his parade vehicle, who spent the reception parked inside a chair and left early while he am uncomfortable, was the last to depart – and powerful enough to help keep the party going.

“You guys will always be cheering for me personally,Inches he told the fans, “so this is actually the least I’m able to do.”

***

Carew joined the Hall of Fame in 1991. He returns most many years to welcome the most recent inductees into baseball’s most revered fraternity.

Last year’s visit came several weeks following a nearly fatal cardiac arrest and cardiac event brought to some device being implanted in the chest to help keep him alive, a piece of equipment known as a left ventricular assist device, or LVAD. Truly being here was significant.

However it would be a struggle. Exhaustion, he thought. The reason switched to be bleeding in the brain, a setback that jeopardized his quest to obtain a new heart – or worse.

As he got the transplant in December, Carew understood he couldn’t travel not less than six several weeks.

Fortunately, Hall of Fame weekend was seven several weeks away.

***

Carew continues to be pushing themself in rehab for 2 hrs 72 hours per week. Since his six-month checkup, he’s already traveled to Minneapolis to become honored in a Twins game and also to Miami to become honored in the All-Star Game.

Everywhere he goes, Carew spreads the term about heart health. That’s the mission of Heart of 29, the campaign using the American Heart Association he and the wife, Rhonda, launched soon after his ordeal started in September 2015.

The campaign required its name in the jersey number Carew used throughout his career. It presently has added meaning: His organ donor, Konrad Reuland, was 29 as he died carrying out a ruptured brain aneurysm.

Reuland was an National football league player, making their heart the very first shared by pro athletes. Much more amazing is the fact that donor and recipient had met Reuland visited exactly the same junior high school as Carew’s children as well as their pathways entered at least one time when Reuland was 11.

The compelling ties that bind this story continue generating attention, widening the achieve of Heart of 29. A news conference ‘life was imple’ provided another chance.

“Konrad Reuland is here now beside me today in the Hall of Fame,” Carew stated. “Konrad travels beside me now because we’re attempting to save lives. …  We’re likely to perform a large amount of great work together.”

Carew held a news conference within the same room this past year, too. Then, he demonstrated the controller and batteries powering his LVAD. This season, he demonstrated the particular mechanism that was once inside him.

“This is, in my experience, similar to magic,Inches he stated. “I feel happy. My heart’s roaring. … It had been a lengthy journey, however it would be a good journey.”

Carew holding his LVAD throughout a news conference.

***

Carew’s next stop was an autograph signing near Primary Street, across in the Hall.

Signs published around the walls put down Carew-specific guidelines: No handshakes. No photos behind the table. It’s a indication that infection is a continuing fear, that as great as he’s doing, trouble can nonetheless be lurking.

Carew was scheduled to sign for 1 1 / 2 hrs. Demand – and the newly found stamina – pressed him beyond two hrs before he requested to chop them back. From the roughly 30 baseball greats here this mid-day, none lasted as lengthy coupled with as numerous customers.

A number of Carew’s visitors came in excess of an autograph.

***

Dave Grey and the boy, Matt, make the hour-plus trek from East Greenbush, New You are able to, many occasions. Mainly Yankees fans, their sole purpose this season was seeing Carew.

Grey is dealing with their own stint by having an LVAD and heart transplant. The LVAD enabled him just to walk his daughter lower the aisle. His second grandchild showed up a couple of several weeks after he received his new heart. The transplant was 11 several weeks ago, and that he still wears a surgical mask in crowds as added defense against infection.

Grey produced a photograph book commemorating his journey. He makes use of it to inspire other patients around the waiting list. He thought getting Carew’s signature would enhance his message.

Dave Grey and Carew.

“Wow,” Carew stated as Grey flipped with the pages.

On the blank page, Carew authored, “May God continue to provide you with his benefits.” He handed it to Grey and stated, “I want to inform you something.”

Out came his LVAD again.

“Imagine this being within us,” Carew stated.

“That’s things i had, too,” Grey stated.

“Did you are feeling it?” Carew stated.

“I could feel it on my small ribs the following,Inches Grey stated, touching the underside left of his rib cage.

“I didn’t,” Carew stated.

There these were, two medical marvels swapping tales. Much like Carew shares a unique bond together with his fellow Hall of Famers, he feels another kind of reference to Grey, a 39-year worker of Owens Corning who loves canning and volunteering in the hospital where his existence was saved.

“Great seeing you,” Carew stated, contacting bump fists.

Following a couple of more and more people file with the line, a youthful man putting on a Montreal Expos hat backward handed Carew a ball to sign.

“How’s your wellbeing, mister?” the fan stated.

“It’s good,” Carew stated, searching lower in the ball.

“I’m a transplant patient myself, mister,” the fan stated. Carew’s mind clicked up.

“Are you?!” Carew stated.

“Yeah, kidney,” the fan stated. “Not badly while you, but nonetheless.Inches

“I were built with a kidney, too,” Carew stated.

“Yeah, how’s it going feeling?” the fan stated.

“I’m feeling good,” Carew stated.

“It’s great – another chance at existence,” the fan stated.

Hall of Famer Craig Larkin was signing autographs in a nearby table. Certainly one of his buddies met Carew right after.

“Mr. Carew, you’re an inspiration,” the person stated, pulling lower in the neck of his shirt to show his heart-surgery scar.

Carew leaned directly into look, then unbuttoned his shirt to show his scar. He exhibited a hot smile and offered another fist bump.

“We’re siblings, you realize,Inches Carew stated.

“Yes,” the person stated, leaning back and supplying a thumb’s up gesture. “Yes, we’re.Inches

***

This past year, the parade provided the emotional crescendo of Carew’s weekend. Someone yelled, “Thanks to be alive,” and Carew didn’t leak tears, because he frequently did throughout his LVAD days, he entered a shoulder-trembling bawl.

This time around, lines like “Keep living!” stored Carew smiling. The exception was seeing several fans placed their hands over their hearts. That switched his eyes watery.

Carew revealing his Hall of Fame plaque throughout the reception.

Carew poses before his place alongside his wife, Rhonda (pink dress) and the mother-in-law, Peggy Fedden (white-colored sweater).

Another memorable moment this past year was the Sunday induction ceremony. It had been Carew’s public low point because he needed to be helped off and on happens, and battled despite the help.

This time around, Carew was introduced together with his usual baseball accolades, capped by emcee John Kenny of Major league baseball Network saying, “This year, the trip to Cooperstown is even more special as with only the past couple of several weeks, he’d both a heart transplant along with a kidney transplant, and the existence continues to be saved. It’s especially wonderful to welcome back this season, Hall of Fame Type of 1991, as well as gentlemen, Fishing rod Carew.”

And out he walked, waving and striding to his place, the roar from the crowd growing with every step.

***

For that Hall of Famers, their highlight from the weekend is really a private dinner on Sunday night – men within their 40s through 80s making up ground and dicing like teenagers.

Carew entered last year’s dinner wondering if he’d ever allow it to be back.

This time around, he held a motion picture-and-tell session. Together with his LVAD, obviously.

The raucous room grew to become silent. Baseball’s best switched to mindful students as Carew described exactly what the device did for him where it’d sitting inside his body.

He passed it around so others could have a look and have the weight – about as heavy as two baseballs. These were awed in what it did and stunned to listen to he never felt it.

Carew closed together with his proactive approach.

He requested who’s become their heart checked? Who’s ensured their loved ones has been doing it? Their buddies?

He then drawn on his heart and stated, “My boy is appropriate here beside me,Inches and requested who’s a body organ donor?

“It was all well-received, too,” Carew stated the following day. “Our message gets through. And that’s all you want to do.”

Certainly one of 36 balls Carew signed with this particular inscription.

The way forward for cardiovascular disease prevention? The way your genome expresses itself

By AMERICAN HEART ASSOCIATION NEWS

The breakthrough made headlines in 2003: Scientists had mapped the DNA sequence that produces the genetic code of humans. Since that time, scientific breakthroughs and transformative technologies have ushered inside a genomic era that is constantly on the peel back layers of knowledge about traits and illnesses for example cardiovascular disease and stroke.

A brand new scientific statement in the American Heart Association delves right into a crucial element of the genome that you’ve likely never heard of — the “expressed genome.” It’s the mixture of molecular-level traits that may predict health and could be altered with a person’s physical atmosphere and lifestyle choices, for example exercise or tobacco use.

“People consider the DNA sequence because the blueprint of existence. However the DNA sequence is simply the beginning point. Whenever we discuss the expressed genome, especially in the statement, you’re by taking your blueprint and building from it,” said Kiran Musunuru, M.D., Ph.D., the statement’s lead author.

A different way to comprehend the expressed genome is as simple as considering a persons genome because the alphabet. The expressed genome is when that alphabet will get arranged in words, sentences and sentences, stated D Arnett, Ph.D., an epidemiology professor and dean from the College of Kentucky’s College of Public Health.

Musunuru noted “a little bit of irrational exuberance” has adopted the conclusion from the Human Genome Project, including recent buzz over DNA tests that customers can perform in your own home.

“Part from the intent of the statement is to provide a realistic look at how complex and extended the procedure could be of going from the discovery that you simply find out about within the newspaper, to really getting something you can use in patients,” stated Musunuru, an affiliate professor of cardiovascular medicine and genetics in the College of Pennsylvania.

The statement, printed Monday in Circulation: Cardiovascular Genetics, highlights two breakthroughs which are now commercially accessible and getting used in clinical practice. One test utilizes a bloodstream sample to discover a specific group of biomarkers, a little subset of RNA molecules that may identify coronary heart in individuals with signs and symptoms that may indicate cardiovascular disease.

Another test enables doctors to look at heart transplant recipients after surgery for indications of organ rejection without needing the standard approach to what basically comes down to a heart biopsy. Rather, technicians can examine a particular group of RNA molecules to evaluate how good the patient’s is accepting the brand new heart.

Musunuru stressed neither test examines genetics, but they are “two types of breakthroughs while using expressed genome which have culminated in commercially accessible tests that the physician can really order.”

Quickly developing technology getting used to review expressed genomes could predict ailments additionally to coronary heart, for example stroke, heart failure and arrhythmia. At this time, doctors are restricted in what they are able to read from traditional tests that measure bloodstream pressure and levels of cholesterol, in addition to exactly what a patient volunteers about personal habits and genealogy.

“But there are lots of individuals who don’t smoke and have high cholesterol levels or high bloodstream pressure who develop cardiovascular disease and stroke anyway,” Arnett stated. “These technology are likely to enable us to identify individuals causes in a more granular level. We could capture stuff that we’re able to not capture before.”

Thomas J. Wang, M.D., the director from the cardiovascular medicine division at Vanderbilt Heart and Vascular Institute in Nashville, stated we’ve got the technology utilized in scientific studies are being developed in an impressive speed.

“Just as if you saw with computer chips and phones, the molecular technologies that are offered for characterizing these various facets of the expressed genome are plowing ahead in a rapid pace,” stated Wang, who had been among the reviewers from the AHA statement. “It’s different pace you may have seen ten or twenty years back. There’s clearly acceleration.”

Also, he noted that how big studies accustomed to test these technologies has expanded considerably.

“In yesteryear, research of the couple 1000 people was the normal size an epidemiologic study that could be used to look for the risks for disease,” he stated. “Now we’re speaking about studies which are within the thousands and thousands.Inches

Or, within the situation of the precision medicine initiative through the National Institutes of Health, a million volunteers are now being employed.

“These massive scientific testing on people may also allow, in conjunction with we’ve got the technology, an faster pace of discovery,” Wang stated.