Umbilical cord stem cells show promise as heart failure treatment

Study Highlights

  • Intravenous stem cell infusion produced from umbilical cords seems to improve heart muscle function in patients with heart failure, based on a little study.
  • Within this first-of-its-kind study, patients had “significant” improvement within their hearts’ capability to pump bloodstream and experienced no adverse negative effects associated with the treatment.
  • The outcomes suggest IV-infused umbilical cord-derived stem cells really are a promising avenue to deal with heart failure.

Embargoed until 3 p.m. CT / 4 p.m. ET Tuesday, September 26, 2017

DALLAS, Sept. 26, 2017 – A heart failure treatment using umbilical cord-derived stem cells can lead to notable enhancements in heart muscle function and excellence of existence, according to a different study printed in Circulation Research, a united states Heart Association journal.

“We are encouraged by our findings simply because they could pave the best way to a non-invasive, promising new therapy for several patients who face harsh odds,” stated study corresponding author Fernando Figueroa, M.D., professor of drugs in the Universidad de los Andes in Chile.

Within this trial, 30 volunteers, ages 18 to 75, with stable heart failure receiving optimal drug therapy went through intravenous infusions with either umbilical cord-derived stem cells or placebo. The umbilical cords were acquired from full-term human placentas from healthy contributors by caesarean section after informed consent.

When compared to placebo treatment, the stem cell therapy:

  • demonstrated sustained and “significant” improvement within the hearts’ capability to pump bloodstream around following treatment
  • led to greater enhancements on measures of daily functional status and excellence of existence and
  • was safe without any negative effects or growth and development of alloantibodies, a typical immune complication in patients receiving organ transplants or bloodstream transfusions.

Scientific study has formerly assessed the potential for bone marrow-derived stem cells as treatment however, intravenous umbilical cord-derived stem cells haven’t been evaluated. The second type continues to be particularly appealing since they’re readily available, broadly available, unlikely to result in immune complications and free from the moral concerns that surround embryonic stem cells, they noted.

“Standard drug-based regimens could be suboptimal in managing heart failure, and patients frequently need to progress to more invasive therapies for example mechanical ventricular assist devices and heart transplantation,” stated lead study author Jorge Bartolucci M.D., a cardiologist from Cells for Cells and professor in the Universidad de los Andes.

Heart failure, marked through the heart muscle’s lack of ability to function bloodstream efficiently, affects some 37 million people worldwide. Despite medical advances, 1 / 2 of patients identified as having heart failure will die within 5 years of diagnosis, based on Figueroa. If affirmed in bigger studies, these bits of information could give a promising new treatment choice for a disorder that presently has couple of.   

Other co-authors incorporated Fernando J. Verdugo, M.D. Paz L. González, B.Sc. Ricardo E. Larrea, M.D. Ema Abarzua, M.D. Carlos Goset, M.D. Pamela Rojo, M.D. Ivan Palma, M.D. Ruben Lamich, M.D. Pablo A. Pedreros, M.D. Gloria Valdivia, Ph.D. Valentina M. Lopez, B.Sc. Carolina Nazzal, Ph.D. Francisca Alcayaga, Ph.D. Jimena Cuenca, Ph.D. Matthew J. Brobeck, B.Sc. Amit N. Patel, M.D. and Maroun Khoury, Ph.D. Author disclosures take presctiption the manuscript.

The research was funded with a grant from CORFO, the Chilean Economic Development Agency.

Additional Sources:

Statements and conclusions of study authors printed in American Heart Association scientific journals are exclusively individuals from the study authors and don’t always reflect the association’s policy or position. The association will not make any representation or guarantee regarding their precision or reliability. The association receives funding mainly from individuals foundations and corporations (including pharmaceutical, device manufacturers along with other companies) also make donations and fund specific association programs and occasions. The association has strict policies to avoid these relationships from influencing the science content. Revenues from pharmaceutical and device corporations and medical health insurance providers can be found at world wide web.heart.org/corporatefunding.

Concerning the American Heart Association

The American Heart Association is dedicated to saving individuals from cardiovascular disease and stroke – the two leading reasons for dying on the planet. We team with countless volunteers to finance innovative research, fight for more powerful public health policies and supply lifesaving tools and knowledge to avoid and treat these illnesses. The Dallas-based association may be the nation’s earliest and largest voluntary organization focused on fighting cardiovascular disease and stroke. To find out more in order to become involved, call 1-800-AHA-USA1, visit heart.org or call any one of our offices round the country. Follow us on Twitter and facebook.

For Media Queries and AHA/ASA Spokesperson Perspective: 214-706-1173

Bridgette McNeill: 214-706-1135 [email protected]

For Public Queries: 1-800-AHA-USA1 (242-8721)

heart.org and strokeassociation.org

Heart failure might be treated using umbilical cord stem cells

small heart held in hands
Scientists offer new expect heart failure patients.
Using stem cells produced from the umbilical cord, scientific study has improved the center muscle and performance of heart failure patients, paving the way in which for noninvasive therapies.

Charge author from the study is Dr. Jorge Bartolucci, a professor in the Universidad de los Andes (UANDES) in Santiago, Chile, and Dr. Fernando Figueroa, a professor of drugs at UANDES, may be the corresponding author.

Dr. Bartolucci and colleagues conducted an effort that they compared patients who have been given an intravenous injection with stem cells from umbilical cords with patients who received a placebo.

The outcomes – which have been printed within the journal Circulation Research – were considered “encouraging” by Dr. Figueroa. He states the findings could improve survival rates for heart failure patients, that are presently quite disappointing.

1 / 2 of all heart failure people are likely to die inside the first five years following the diagnosis, and also the 10-year rate of survival is under 30 %. Worldwide, 26 million individuals are thought to accept the problem.

In heart failure, the heart’s muscles weaken and can’t pump bloodstream adequately through the body. Worryingly, the specter of heart failure is growing among individuals the U . s . States the amount of people affected is presently set at 6.5 million, which is likely to rise by 46 percent through the year 2030.

The authors from the new study observe that previous studies have already looked into the potential for stem cells produced from bone marrow for the treatment of heart failure, however they state that umbilical cord-derived stem cells haven’t been examined.

They are a far more desirable avenue for treatment, the authors add, because they are readily available, don’t pose the ethical concerns that embryonic stem cells do, and will not elicit an adverse immune response.

Treatment proves safe and efficient

Within their small trial, Dr. Bartolucci and team divided 30 volunteers – aged between 18 and 75 – into two small groups: one received treatment, and yet another received a placebo.

Patients both in groups had stable heart failure, that was appropriately given the conventional drugs.

The stem cells utilized by they were produced from umbilical cords, that have been acquired from human placentas. These have been donated by healthy moms who transported their pregnancy to term coupled with a cesarean delivery.

It had been discovered that within the stem cell group, the treatment improved the hearts’ capability to pump bloodstream around following the treatment. The stem cell therapy also appeared to enhance the daily functioning and excellence of existence of individuals treated.

No negative effects or inflammatory immune responses were noted throughout the treatment, even though typically, patients who receive bloodstream transfusions are vulnerable to adverse immune reactions.

The therapy was “achievable and safe,” the authors conclude, also it “led to a substantial improvement in left ventricular function, functional status, and excellence of existence.”

“These bits of information suggest [the intervention] could have an affect on clinical outcomes, supporting further testing through large numerous studies,Inch they add.

This kind of stem cell therapy might be very advantageous to heart failure patients, repeat the authors, especially in comparison with existing treatments.

“Standard drug-based regimens could be suboptimal in managing heart failure, and patients frequently need to progress to more invasive therapies for example mechanical ventricular assist devices and heart transplantation,” explains Dr. Bartolucci.

We’re encouraged by our findings simply because they could pave the best way to a noninvasive, promising new therapy for several patients who face harsh odds.”

Dr. Fernando Figueroa

A brand new expect heart failure originates from umbilical cords

By AMERICAN HEART ASSOCIATION NEWS

A new study shows stem cells from umbilical cord blood may be safe and effective in treating heart failure. This image shows umbilical cord stem cells co-cultured with rat heart cells in vitro. (Courtesy of Cells for Cells)

New research shows stem cells from umbilical cord bloodstream might be effective and safe for heart failure. This picture shows umbilical cord stem cells co-cultured with rat heart cells in vitro. (Thanks to Cells for Cells)

The bloodstream from the baby’s umbilical cord is teeming with stem cells — the “blank slate” cells having the ability to be a muscle cell, a brain cell or other kind of cell in your body.

A group of scientists in Chile used stem cells from umbilical cords to deal with heart failure inside a first-of-its-kind study. Findings in the early-phase study were printed Tuesday in Circulation Research.

The study team found stem cell infusions were safe and led to significant improvement within the heart’s capability to pump bloodstream around following treatment. Patients finding the stem cell therapy also saw their signs and symptoms lessen and excellence of existence improve.

Fernando Figueroa, M.D., a investigator in the College from the Andes in Santiago who labored around the study, stated it had been notable that “a single intravenous infusion of those cells would exert lengthy-lasting effects on heart function and excellence of existence in patients otherwise under optimal treatment, but nonetheless facing limitations.”

The outcome of stem cell therapy for heart failure continues to be studied for over a decade. Past research has centered on hard-to-harvest stem cells obtained from bone marrow, however the new study marks the very first time umbilical cord-derived stem cells happen to be tested intravenously in heart failure patients.

Among 30 heart failure patients with reduced ejection fraction, also referred to as systolic heart failure, half received intravenous infusions of umbilical cord-derived stem cells and half received a placebo. Systolic heart failure takes place when the left ventricle stops contracting normally and also the heart loses the opportunity to push enough bloodstream into circulation.

Using stem cells from umbilical cords has lots of advantages over using stem cells from bone marrow, Figueroa stated.

“This is really a non-invasive procedure. The cell source is obtainable, has relatively low processing costs with no ethical conflict,” he stated. “It comes with an extensive history for safety since it’s been used in more detail in patients with a variety of conditions, without any reported negative effects.Inches

Figueroa stated some scientists believe secretions in the stem cells have regenerative effects on heart tissue. Many scientists also believe cells work well for heart failure due to the way they decrease damage brought on by the defense mechanisms.

“While the defense mechanisms is essential to safeguard from infectious disease and malignancy, it may also cause harm when activated after an inflammatory event, like a cardiac arrest, and result in destruction of tissues and cells,Inches stated pathologist David McKenna, M.D., that has conducted studies on umbilical cord bloodstream along with other cellular therapies in the College of Minnesota. McKenna wasn’t active in the new study.

These kinds of stem cells, he stated, happen to be proven to modulate or turn lower the harmful results of the defense mechanisms by producing protective molecules.

Figueroa stated his research group has been doing a 3-year follow-as much as observe how patients in the study fare lengthy-term. His research team may also still study umbilical cord-derived stem cells in addition to stem cells using their company sources, for example menstrual fluid.

Meanwhile, Figueroa stated he’s waiting to determine the outcomes of two other ongoing studies involving cardiovascular disease and umbilical cord-derived stem cells, including one which administers the stem cells through intracoronary injections rather of intravenously.

He stated there is a pressing requirement for bigger, more in depth studies during the period of “many years” to know the entire potential of stem cells — not only to treating heart failure, but other illnesses too.

“We know only area of the picture … the entire mechanism remains unraveled,” he stated.

For those who have questions or comments relating to this story, please email [email protected]