Researchers claim that nutritional potassium may help to safeguard against cardiovascular disease.
Scientific study has discovered that rodents with low nutritional potassium are more prone to experience vascular calcification, that is sign of coronary artery disease. This really is major risk factor for cardiovascular disease.
Growing nutritional potassium, however, was discovered to lessen vascular calcification within the rodents, suggesting that the diet wealthy in potassium may help to avoid cardiovascular disease.
The study team – brought by Yabing Chen, Ph.D., a professor of pathology in the College of Alabama at Birmingham (UAB) – lately reported their findings in JCI Insight.
Cardiovascular disease may be the leading reason for dying for both women and men within the U . s . States, killing around 610,000 people in the united states each year.
Coronary artery disease is really a key risk factor for cardiovascular disease. In coronary artery disease, deposits of fat, cholesterol, calcium, along with other substances accumulate within the arterial blood vessels, developing what is called “plaque.” Plaque hardens with time, restricting bloodstream flow towards the heart.
The brand new research from Prof. Chen and colleagues shows that potassium supplementation might be one method to help combat coronary artery disease and prevent cardiovascular disease.
Potassium and vascular calcification
Potassium is really a mineral that’s considered required for the body. It-not only aids muscle contraction and nerve and cell function, it helps you to regulate the heartbeat.
Green spinach along with other leafy vegetables, in addition to taters, carrots, oranges, and grapefruit, a few of the vegetables and fruit which are good causes of potassium. The mineral can also be like a nutritional supplement.
For his or her study, they given rodents high-fat diets supplemented with either low, normal, or high amounts of potassium. The rodents used were deficient inside a protein known as apolipoprotein E, making rodents weaker to coronary artery disease as a result of a higher-fat diet.
They discovered that rodents given a minimal-potassium diet demonstrated a rise in vascular calcification and greater arterial stiffness, while rodents given a higher-potassium diet demonstrated a substantial decrease in both conditions.
They also assessed the results of different potassium levels on cultured vascular smooth muscle tissues from rodents, and also on cultured mix parts of mouse arterial blood vessels.
Study has ‘important translational potential’
The cell culture analysis says via a potassium transport funnel known as the inward rectifier potassium funnel, low-potassium conditions brought to a rise in intracellular calcium in vascular smooth muscle tissues.
Also, they discovered that low potassium triggers the calcium-activated cAMP response element-binding protein (CREB), which increases autophagy – an intracellular degradation process – in cells.
By inhibiting autophagy, they found that they are in a position to prevent calcification in vascular smooth muscle tissues, indicating that autophagy plays a substantial role within the calcification process.
Through their analysis of cultured mix parts of mouse arterial blood vessels and nutritional experiments in live rodents, they confirmed that low potassium can lead to vascular calcification via calcium signaling, CREB, and autophagy. Growing potassium levels, however, could reduce these effects.
While scientific testing on people are actually required to demonstrate the effectiveness of potassium against vascular calcification in humans, they think that their current findings show promise.
“The findings have important translational potential, given that they demonstrate the advantage of sufficient potassium supplementation on protection against vascular calcification in coronary artery disease-prone rodents, and also the adverse aftereffect of low potassium intake.”
Study co-author Dr. Paul Sanders, UAB Department of drugs