E-cigarette vapor slows heartbeat in rodents

Embargoed until 3 p.m. PT/ 6 p.m. ET, Sunday, November. 12, 2017

ANAHEIM, California, November. 12, 2017 — Electronic nicotine delivery systems (ENDS) for example e-cigarettes, affect heart rhythm and cardiovascular function in rodents, based on research presented in the American Heart Association’s Scientific Sessions 2017, a top-notch global exchange from the latest advances in cardiovascular science for researchers and clinicians.

Additionally to nicotine, e-cigarette products usually contain propylene glycol (PG) and/or vegetable glycerin (VG). These substances are generally accustomed to limit moisture reduction in agents or as food additives, however the health results of heating and inhaling these substances are unknown.

Within this study, researchers examined the cardiovascular results of e-cigarette aerosols in accordance with traditional cigarettes in rodents and located:

  • Contact with ENDS aerosol or traditional tobacco smoke quickly slowed the center rate (bradycardia) in rodents.
  • Contact with aerosol of fifty:50 vegetable glycerin and propylene glycol prolonged the heart’s electrical cycle.
  • When heated, propylene glycol and/or vegetable glycerin generate aldehydes, acrolein, acetaldehyde, and chemicals, which, only acrolein caused bradycardia in rodents.
  • Contact with acrolein or PG:VG aerosol elevated bloodstream pressure in rodents prior to the heartbeat started to decrease.

Researchers say further studies are necessary to explore these effects in humans using ENDS. These bits of information claim that contact with ENDS aerosols may trigger cardiovascular effects and could raise the perils of developing irregular heart rhythm and overall coronary disease.

Authors are Alex P. Carll, Ph.D. Renata Salatini, Ph.D. Claudia Arab, Ph.D. Daniel G. Holbrook, Ph.D., Aruni Bhatnagar, Ph.D. and Daniel J. Conklin, Ph.D.

National Institutes of Health funded the research.

Daniel Conklin, Ph.D., College of Louisville, Kentucky.

Note: Scientific presentation is 3:15 p.m. PT, Sunday, November. 12, 2017.

Presentation location: Population Science Section, Science Hall

Additional Sources:

Statements and conclusions of study authors which are presented at American Heart Association scientific conferences are exclusively individuals from the study authors and don’t always reflect association policy or position. The association will not make any representation or warranty regarding their precision or reliability. The association receives funding mainly from individuals foundations and corporations (including pharmaceutical, device manufacturers along with other companies) also make donations and fund specific association programs and occasions. The association has strict policies to avoid these relationships from influencing the science content. Revenues from pharmaceutical and device corporations can be found at world wide web.heart.org/corporatefunding.

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Concerning the American Heart Association

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